To investigate the antihyperglycemic and antioxidant properties of the petroleum ether extract of Platycladus orientalis leaves in streptozotocin-induced diabetic rats, hyperglycemia was induced in rats by streptozotocin (STZ, 45 mg/kg body weight). Three days after STZ induction, diabetic rats received Platycladus extract at 100 and 200 mg/kg body weight daily for 28 days. Glibenclamide (600 µgm/kg) served as reference. Blood glucose levels were measured on every 7th day during 28 days. Serum biochemical parameters low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), atherogenic index and the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP)were estimated. Antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), serum thiobarbituric (TBAR) was measured in the diabetic rats. Therefore, Platycladus orientalis demonstrated remarkable antidiabetic activity in STZ induced diabetic rats. The potential antidiabetic action is plausibly due to its modulation of endogenous antioxidant status. Administration of the extracts for 28 days caused a significant (P<0.01) reduction in blood glucose levels in diabetic mice. The extracts also improved other altered biochemical parameters associated with diabetes. Furthermore, the extracts have favorable effects on the histopathological changes of the pancreas, in STZ induced diabetic mice. The extracts also showed significant (P<0.05) antioxidant activity. Platycladus orientalis possesses antihyperglycemic and antioxidant properties as well improved lipid profile.
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